For daily cleanings of a cleanroom, when should cleaning be performed?

Cleaning a cleanroom is essential for maintaining a controlled environment where sterile compounding occurs. The most effective practice is to clean the cleanroom at the end of the day after compounding has been completed. This approach allows for the removal of any potential contaminants that may have been introduced during the compounding process and ensures that the environment is sanitized and ready for the next day's operations. By performing cleaning at this time, any spills, dust, or residues left from the day's activities can be addressed effectively, thereby minimizing the risk of cross-contamination and maintaining compliance with regulatory standards essential for sterile compounding.

While cleaning at the start of the day is important, it does not account for any contamination that may occur during compounding activities throughout the day. Cleaning only before compounding begins may not adequately address any debris or contaminations that happen during the operational hours. Cleaning once a week is insufficient for a cleanroom environment where sterile products are compounded, as such extended intervals would allow for a significant buildup of contaminants. Daily cleaning, particularly at the day's end, is critical for ensuring the integrity and safety of compounded medications.