Which drug schedule must be ordered using a DEA 222 form?

The correct answer pertains to Schedule II controlled substances, which must be ordered using a DEA 222 form. This requirement exists because Schedule II drugs have a high potential for abuse and can lead to severe psychological or physical dependence. The DEA 222 form is necessary to track the distribution and handling of these substances, ensuring that there is proper accountability and oversight in their supply chain.

The process of using the DEA 222 form helps prevent illegal diversion and misuse of these highly regulated drugs. It allows pharmacists and healthcare providers to maintain a clear record of transactions involving Schedule II substances, creating a transparent audit trail for regulatory purposes.

In contrast, Schedule III, IV, and V substances have less stringent ordering requirements and do not necessitate the use of a DEA 222 form. Instead, these classifications can often be ordered via standard invoice methods, reflecting their lower potential for abuse compared to Schedule II drugs.