Which of the following items is NOT categorized as a controlled substance?

Acetaminophen is not categorized as a controlled substance because it does not have a significant potential for abuse or dependence compared to the other options listed. Controlled substances are specifically defined by their potential for addiction and abuse, as well as their accepted medical use. Medications like hydrocodone, oxycodone, and methadone are classified as controlled substances due to their opioids nature, which leads to a higher risk of abuse and addiction. Acetaminophen, commonly known for its pain-relieving properties, is considered a safe and effective over-the-counter medication when used as directed, and thus, does not fall under the same regulatory restrictions as controlled substances.