Which of the following statements about cocaine hydrochloride is true?

Cocaine hydrochloride is indeed a topical anesthetic that can be used in specific medical contexts, demonstrating that the first statement is accurate. This use is allowed in procedures that require localized anesthesia—and the application must follow proper medical guidelines.

The second statement touches on the use of Schedule II stimulants for treating closed head injuries. Although this can seem controversial, typically these medications are not indicated for managing such injuries due to the potential for misuse and side effects, even if they might be part of a broader treatment strategy for certain specific cases.

The third statement regarding anabolic steroids and human growth hormone points to the consensus in sports medicine and ethics that these substances should not be employed for performance enhancement. There are solid regulations against their use in competitive athletics due to the health risks involved and the unfair advantage they provide.

Choosing the option that validates three statements as true aligns with the established medical understanding surrounding these substances. This option accurately reflects critical insights into their use and regulation in medical and athletic contexts.